Traditionally, SVM training data is labeled by an expert,
The role of deoxyribonucleic acids in the cell has made DNA an attractive target for drug molecules. The anthracycline antitumour antibiotics are potent cytotoxic agents that have found widespread use in cancer chemotherapy. Nogalamycin binds DNA through intercalation, preferentially to 5′ TpG and 5′ CpG sites steroids, by threading through the DNA helix and interacting with both the major and minor grooves simultaneously.In this thesis, the interaction of nogalamycin with the 5′ TpG site has been investigated using synthetic oligonucleotide duplexes and a combination of high resolution NMR techniques and NOE restrained molecular dynamics simulations.
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