Once generated and the files are unpacked from the program
The first chapter treats the geometry of the spaces. Their homogeneous structure and their invariant connections are studied. The existence of a canonical invariant almost product structure is pointed out. It is established that patients with knee osteoarthritis (OA) exhibit marked muscle weakness, one of the most frequent and earliest reported symptoms associated with knee OA. Weakness primarily affects the quadriceps muscle with little evidence of hamstring involvement. Traditionally, muscle weakness has been considered a secondary effect in knee OA, resulting from disuse of the affected joint due to the presence of pain and/or inflammation, and therefore has received little attention with regards to its involvement in the initiation or progression of OA.
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